{"id":1223,"date":"2026-04-29T22:34:09","date_gmt":"2026-04-29T22:34:09","guid":{"rendered":"http:\/\/alliance-co2-solutions.org\/?p=1223"},"modified":"2026-04-29T22:34:09","modified_gmt":"2026-04-29T22:34:09","slug":"synchronous-metastasis-occurred-in-78-patients-and-metachronous-metastasis-or-relapse-occurred-in-76-patients","status":"publish","type":"post","link":"https:\/\/alliance-co2-solutions.org\/?p=1223","title":{"rendered":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients"},"content":{"rendered":"

\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients. characteristics and gene polymorphisms were evaluated in univariate and multivariate analysis as predictive factors for response rate (RR) and progression-free survival (PFS). In patients bearing 24 genotypes ofMTHFR677C\/C,MTHFR1298 A\/C or C\/C,ABCG234G\/G, andABCG2421C\/A or A\/A, those who received oxaliplatin-based chemotherapy achieved a higher RR (41.7 vs. 18.8 %,P= 0.027) and longer median PFS (mPFS) than irinotecan-based therapy [8.9 vs. 7.1 m, FOLFIRI: hazard ratio (HR) = 1.722, 95 % confidence interval (CI) 1.0262.892,P= 0.040, compared with FOLFOX\/XELOX]; on the contrary, patients transporting 0 or 1 above genotype exhibited better outcomes after receiving FOLFIRI chemotherapy (mPFS: 9.3 vs. 6.4 m, FOLFIRI: HR = 0.422, 95 % CI 0.2050.870,P= 0.019, compared with FOLFOX\/XELOX). Combination of SNPs withMTHFRandABCG2may play a role in helping clinicians to select first-line chemotherapy for patients with metastatic colorectal malignancy. Keywords:Colorectal neoplasms, Oxaliplatin, Irinotecan, Polymorphisms,MTHFR,ABCG2 == Introduction == Colorectal malignancy (CRC) is one of the generally diagnosed cancers among patients, which ranks the third for males and the second for females worldwide. For the fatality rate, it ranks the fourth and the third for males and females, respectively [1]. Systemic combination chemotherapy is the mainstay of the treatment for patients with metastatic colorectal malignancy (mCRC). Treatment for patients with mCRC has evolved significantly over the last 10 years with the use of new active cytotoxic brokers, including oxaliplatin and irinotecan plus targeted monoclonal antibodies bevacizumab, cetuximab, and panitumumab; 5-fluoropyrimidine (5-FU), leucovorin (CF), and oxaliplatin (FOLFOX), capecitabine, and oxaliplatin (XELOX) or 5-FU, CF, Rabbit polyclonal to Neurogenin2<\/a> and irinotecan (FOLFIRI) are the standard chemotherapy treatment Dicyclanil for metastatic colorectal malignancy in practice with comparative treatment effectiveness [24]. However, some patients do not necessarily benefit from the treatment they have received, but are exposed to the adverse effects nonetheless [5]. Therefore, it is of great importance to identify biomarkers that could help select the optimum regimen for each patient. Genetic polymorphisms in drug target genes, genes encoding DNA repair enzymes, and detoxification pathways may influence the activity of the drug. Single nucleotide polymorphism (SNP) refers to the DNA sequence polymorphisms caused by single nucleotide variations occurred at the genomic Dicyclanil level with the probability greater than 1 %, which sometimes can affect the expression or activity of its encoded protein and therefore affects its function. With respect to the malignancy treatment, SNP would be related to different therapeutic efficacy and adverse reactions. As the common drug in FOLFOX, XELOX, and FOLFIRI regimens, 5-FU or its derivate remains the basis for colorectal malignancy chemotherapy. Optimal cytotoxicity of fluoropyrimidines requires elevated 5, 10-methylenetetrahydrofolate (CH2FH4) tumoral concentrations, controlled by the methylenetetrahydrofolate reductase (MTHFR) enzyme, which irreversibly converts CH2FH4 into 5-methyltetrahydrofolate. TheMTHFRgene is subject to several polymorphisms, of which the 677C>T and 1298A>C SNPs are the two most commonly linked with altered enzyme activity. Accordingly, experimental data have shown that rareMTHFRvariants in position 677 and 1298 are more sensitive to 5-FU [69]. However, results of clinical data do not concord regarding the influence ofMTHFRgenotype on 5-FU responsiveness or patients survival [1012]. Breast cancer resistance protein (BCRP\/ABCG2) is an ATP-binding cassette transporter, which may directly cause resistance of malignancy cells by active efflux of anticancer drugs. It has been found that you will find more than 40 SNPs inABCG2gene, the most common two of which are the 421C>A in exon 5 and 34G>A Dicyclanil<\/a> in exon 2. Numerous in vitro studies have shown that 421A cells have a reduced resistance to irinotecan and its active product SN-38 [13,14], while the polymorphisms of 421C>A inABCG2gene has no effect on the pharmacokinetics of hydrochloric acid irinotecan based on the blood sample from 84 European patients [15]. As forABCG234G>A, Mcleod.<\/p>\n","protected":false},"excerpt":{"rendered":"

\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients. characteristics and gene polymorphisms were evaluated in univariate and multivariate analysis as predictive factors for response rate (RR) and progression-free survival (PFS). In patients bearing 24 genotypes ofMTHFR677C\/C,MTHFR1298 A\/C or C\/C,ABCG234G\/G, andABCG2421C\/A or A\/A, those who received oxaliplatin-based chemotherapy achieved […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"class_list":["post-1223","post","type-post","status-publish","format-standard","hentry","category-et-receptors","no-featured-image"],"yoast_head":"\n\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/alliance-co2-solutions.org\/?p=1223\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease\" \/>\n<meta property=\"og:description\" content=\"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients. characteristics and gene polymorphisms were evaluated in univariate and multivariate analysis as predictive factors for response rate (RR) and progression-free survival (PFS). In patients bearing 24 genotypes ofMTHFR677C\/C,MTHFR1298 A\/C or C\/C,ABCG234G\/G, andABCG2421C\/A or A\/A, those who received oxaliplatin-based chemotherapy achieved […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/alliance-co2-solutions.org\/?p=1223\" \/>\n<meta property=\"og:site_name\" content=\"MCT1 inhibitor in Alzheimer\u2019s disease\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-29T22:34:09+00:00\" \/>\n<meta name=\"author\" content=\"editor\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223\"},\"author\":{\"name\":\"editor\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/#\\\/schema\\\/person\\\/a2b0326f36b85c0b32bd36cafe75b703\"},\"headline\":\"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients\",\"datePublished\":\"2026-04-29T22:34:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223\"},\"wordCount\":616,\"articleSection\":[\"ET Receptors\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223\",\"url\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223\",\"name\":\"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/#website\"},\"datePublished\":\"2026-04-29T22:34:09+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/#\\\/schema\\\/person\\\/a2b0326f36b85c0b32bd36cafe75b703\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?p=1223#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/#website\",\"url\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/\",\"name\":\"MCT1 inhibitor in Alzheimer\u2019s disease\",\"description\":\"Just another WordPress site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/#\\\/schema\\\/person\\\/a2b0326f36b85c0b32bd36cafe75b703\",\"name\":\"editor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g\",\"caption\":\"editor\"},\"sameAs\":[\"http:\\\/\\\/alliance-co2-solutions.org\"],\"url\":\"https:\\\/\\\/alliance-co2-solutions.org\\\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/alliance-co2-solutions.org\/?p=1223","og_locale":"en_US","og_type":"article","og_title":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease","og_description":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients. characteristics and gene polymorphisms were evaluated in univariate and multivariate analysis as predictive factors for response rate (RR) and progression-free survival (PFS). In patients bearing 24 genotypes ofMTHFR677C\/C,MTHFR1298 A\/C or C\/C,ABCG234G\/G, andABCG2421C\/A or A\/A, those who received oxaliplatin-based chemotherapy achieved […]","og_url":"https:\/\/alliance-co2-solutions.org\/?p=1223","og_site_name":"MCT1 inhibitor in Alzheimer\u2019s disease","article_published_time":"2026-04-29T22:34:09+00:00","author":"editor","twitter_card":"summary_large_image","twitter_misc":{"Written by":"editor","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/alliance-co2-solutions.org\/?p=1223#article","isPartOf":{"@id":"https:\/\/alliance-co2-solutions.org\/?p=1223"},"author":{"name":"editor","@id":"https:\/\/alliance-co2-solutions.org\/#\/schema\/person\/a2b0326f36b85c0b32bd36cafe75b703"},"headline":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients","datePublished":"2026-04-29T22:34:09+00:00","mainEntityOfPage":{"@id":"https:\/\/alliance-co2-solutions.org\/?p=1223"},"wordCount":616,"articleSection":["ET Receptors"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/alliance-co2-solutions.org\/?p=1223","url":"https:\/\/alliance-co2-solutions.org\/?p=1223","name":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients - MCT1 inhibitor in Alzheimer\u2019s disease","isPartOf":{"@id":"https:\/\/alliance-co2-solutions.org\/#website"},"datePublished":"2026-04-29T22:34:09+00:00","author":{"@id":"https:\/\/alliance-co2-solutions.org\/#\/schema\/person\/a2b0326f36b85c0b32bd36cafe75b703"},"breadcrumb":{"@id":"https:\/\/alliance-co2-solutions.org\/?p=1223#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/alliance-co2-solutions.org\/?p=1223"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/alliance-co2-solutions.org\/?p=1223#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/alliance-co2-solutions.org\/"},{"@type":"ListItem","position":2,"name":"\ufeffSynchronous metastasis occurred in 78 patients, and metachronous metastasis or relapse occurred in 76 patients"}]},{"@type":"WebSite","@id":"https:\/\/alliance-co2-solutions.org\/#website","url":"https:\/\/alliance-co2-solutions.org\/","name":"MCT1 inhibitor in Alzheimer\u2019s disease","description":"Just another WordPress site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/alliance-co2-solutions.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/alliance-co2-solutions.org\/#\/schema\/person\/a2b0326f36b85c0b32bd36cafe75b703","name":"editor","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f4dcc14beeefbe081cae764d647559acc93d9c15b285756a5f3113c02d044c11?s=96&d=mm&r=g","caption":"editor"},"sameAs":["http:\/\/alliance-co2-solutions.org"],"url":"https:\/\/alliance-co2-solutions.org\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/posts\/1223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1223"}],"version-history":[{"count":1,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/posts\/1223\/revisions"}],"predecessor-version":[{"id":1224,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=\/wp\/v2\/posts\/1223\/revisions\/1224"}],"wp:attachment":[{"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alliance-co2-solutions.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}